Publications

  1. E. Niezabitowska, D. M. Gray, E. Gallardo-Toledo, A. Owen, S. P. Rannard, T. O. McDonald, Understanding the Degradation of Core-Shell Nanogels Using Asymmetrical Flow Field Flow Fractionation, Journal of Functional Biomaterials, 2023, 14 (7), 346; https://doi.org/10.3390/jfb14070346
  2. H. Elkateb, H. Cauldbeck, E. Niezabitowska, C. Hogarth, K. Arnold, S. Rannard, T. O McDonald, High drug loading solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsions for the dual drug delivery of the HIV drugs darunavir and ritonavir JCIS Open, 2023, 11, 100087.
  3. N. M. Elbaz, L. M. Tatham, A. Owen, S.Rannard, T. O. McDonald, Layer by layer self-assembly for coating a nanosuspension to modify drug release and stability for oral delivery, Food Hydrocolloids, 2023, 108908.

  4. J. Taylor, A. Sharp, S. Rannard, S.Arrowsmith, T. O. McDonald, Nanomedicine strategies to improve therapeutic agents for the prevention and treatment of preterm birth and future directions, Nanoscale Adv., 2023, 5, 1870-1889

  5. B. Zhang, S. Petcher, R. A. Dop, P. Yan, W. Zhao, H. Wang, L. J. Dodd, T. O. McDonald, T. Hasell, Inverse vulcanised sulfur polymer nanoparticles prepared by antisolvent precipitation, Journal of Materials Chemistry A, 2022, 10, 26, 13704-13710.
  6. A. Shakil, F. Y. Hern, C. Liu, K. Temburnikar, P. Chambon, N. Liptrott, T. O. McDonald, M. Neary, A. Owen, C. F. Meyers, S. P. Rannard Linear and branched polymer prodrugs of the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine as structural materials for long-acting implants Journal of Materials Chemistry B, 2022, 10, 4395-4404.
  7. D. M. Gray, A. R. Town, E. Niezabitowska, S. P. Rannard, T. O. McDonald, Dual-responsive degradable core–shell nanogels with tuneable aggregation behaviour, RSC advances, 12 (4), 2196-2206
  8. J. Turner, D. A. O’Loughlin, P. Green, T. O. McDonald, and K. J. Hamill, In Search of the Perfect Tan: Chemical Activity, Biological Effects, Business Considerations, and Consumer Implications of Dihydroxyacetone Sunless Tanning Products, Journal of Cosmetic Dermatology, 2022; 00: 1– 10. doi:10.1111/jocd.14968.
  9. C. Hogarth, K. Arnold, A. McLauchlin, S. P. Rannard, M. Siccardi, T. O McDonald, Evaluating the impact of systematic hydrophobic modification of model drugs on the control, stability and loading of lipid-based nanoparticles Journal of Materials Chemistry B, 2021, 9, 9874-9884.
  10. N. M. Elbaz, L. M. Tatham, A. Owen, S. Rannard, T. O.  McDonald Redispersible Nanosuspensions as a Plausible Oral Delivery System for Curcumin. Food Hydrocolloids, 2021, 121, 107005.
  11. J. J. Hobson, A. C. Savage, A. B. Dwyer, C. Unsworth, J. Massam, U. Arshad, H. Pertinez, H. Box, L. Tatham, R. KR. Rajoli, M. Neary, J. Sharp, A. Valentijn, C. David, P. Curley, N. J. Liptrott, T. O. McDonald, A. Owen, S. P. Rannard Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection Nanoscale, 2021, 13, 6410-6416.
  12. L. Johnson, D. M. Gray, E. Niezabitowska, T. O. McDonald. Multi-stimuli-responsive aggregation of nanoparticles driven by the manipulation of colloidal stability. Nanoscale.  (Review Article) 2021, 13, 7879-7896 10.1039/D1NR01190A
  13. S. Rannard, T. O. McDonald and A. Owen. Chasing COVID‐19 chemotherapeutics without putting the cart before the horse. British Journal of Pharmacology. 2020, 1-3.
  14. J. M. Taylor, K. Scale, S. Arrowsmith, A. Sharp, S. Flynn, S. Rannard and T. O. McDonald. Using Pyrene to Probe the Effects of Poloxamer Stabilisers on Internal Lipid Microenvironments in Solid Lipid Nanoparticles  Nanoscale Advances, 2020, 10.1039/D0NA00582G
  15. E. Niezabitowska, A. R. Town, B. Sabagh, M. D. Morales Moctezuma, V. R. Kearns, S. G. Spain, S. P. Rannard, T.O McDonald, Insights into the internal structures of nanogels using a versatile asymmetric-flow field-flow fractionation method, Nanoscale Advances, 2020, 10.1039/D0NA00314J
  16. H. Elkateb, L. M Tatham, H. Cauldbeck, E. Niezabitowska, A. Owen, S. Rannard, T. O. McDonald, Optimization of the synthetic parameters of lipid polymer hybrid nanoparticles dual loaded with darunavir and ritonavir for the treatment of HIV, International Journal of Pharmaceutics, 2020, 588, 119794.
  17. N. M. Elbaz, A. Owen, S. Rannard, T. O. McDonald, Controlled synthesis of calcium carbonate nanoparticles and stimuli-responsive multi-layered nanocapsules for oral drug delivery, International Journal of Pharmaceutics, 2020, 574, 118866
  18. A. R. Town, E. Niezabitowska, J. Kavanagh, M. Barrow, V. Kearns, E. García-Tuñón, T. O. McDonald, Understanding the Phase and Morphological Behavior of Dispersions of Synergistic Dual-Stimuli Responsive poly (N-isopropylacrylamide) Nanogels, The Journal of Physical Chemistry B, 10.1021/acs.jpcb.9b04051
  19. A. R. Town, J. Taylor, K.Dawson, E. Niezabitowska, N. M .Elbaz, A. Corker, E. Garcia-Tuñón, T. O. McDonald, Tuning HIV drug release from a nanogel-based in situ forming implant by changing nanogel size, Journal of Materials Chemistry B, 2019, 7, 373-383.
  20. N. J. Liptrott, M. Giardiello, T. O. McDonald, S. P. Rannard, A. Owen, Assessment of interactions of efavirenz solid drug nanoparticles with human immunological and haematological systems, Journal of nanobiotechnology, 2018 16:22.
  21. R. T. Woodward, F. Markoulidis, F. De Luca, D. B. Anthony, D. Malko, T. O. McDonald, M.SP. Shaffer, A. Bismarck, Carbon foams from emulsion-templated reduced graphene oxide polymer composites: electrodes for supercapacitor devices,Journal of Materials Chemistry A, 2018, 6, 1840-1849.
  22. E. Niezabitowska, J.Smith, M. R. Prestly, R.Akhtar, F. W. von Aulock, Y. Lavallée, H.Ali-Boucetta, T. O. McDonald, Facile production of nanocomposites of carbon nanotubes and polycaprolactone with high aspect ratios with potential applications in drug delivery RSC Advances, 2018, 8, 16444-16454
  23. H. Cauldbeck, M. Le Hellaye, T. O. McDonald, M. Long, R. L. Williams, S. P. Rannard, V. R. Kearns, Modulated Release from Implantable Ocular Silicone Oil Tamponade Drug Reservoirs Journal of Polymer Science. Part A, Polymer Chemistry, 2018, 10.1002/pola.28973.
  24. E. R. Draper, B. Dietrich, C. Brasnett, S. Sproules, T. O. McDonald, A. M. Seddon, D. J. Adams, P‐Type Low‐Molecular‐Weight Hydrogelators, 2018, 10.1002/marc.201700746
  25. P. Curley, M. Giardiello, N. J. Liptrott, D. Dickens, D. M. Moss, J. J. Hobson, A. C. Savage, T. O. McDonald, M. Siccardi, S. Rannard, A. Owen, In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line ,Journal of Interdisciplinary Nanomedicine 2017, 2 (3), 157-169.
  26. N. J Liptrott, M. Giardiello, T. O. McDonald, S. P. Rannard, A. Owen, Lack of interaction of lopinavir solid drug nanoparticles with cells of the immune system. Nanomedicine, 2017,12, 17.
  27. M. E. Levere, P. Chambon, S. P. Rannard, T. O. McDonald, MADIX Polymerization of Vinyl Acetate Using Ethyl Acetate as a Green Solvent; Near-Complete Monomer Conversion with Molecular Weight Control. Journal of Polymer Science, Part A: Polymer Chemistry, 2017, 55, 2427–2431.
  28. P. Curley, M. Giardiello, N. J. Liptrott, D. Dickens, D. M. Moss, J. J. Hobson, A. C. Savage, T. O. McDonald, M. Siccardi, S. Rannard, A. Owen In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. Journal of Interdisciplinary Nanomedicine, 2017.
  29. A. R. Town, M. Giardiello, R. Gurjar, M. Siccardi, M. E. Briggs, R. Akhtar, T. O. McDonald, Dual-stimuli responsive injectable microgel/solid drug nanoparticle nanocomposites for release of poorly soluble drugs. Nanoscale, 2017, 9, 6302-6314.
  30. M. Giardiello, N. J. Liptrott, T. O. McDonald, D. Moss, M. Siccardi, P. Martin, D. Smith, R. Gurjar, S. P. Rannard, A. Owen. Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies. Nature Communications. 2016, 7, 13184.
  31. M. Siccardi, P. Martin, D. Smith, P. Curley, T. O. McDonald, M. Giardiello, N. Liptrott, S. Rannard, A. Owen Towards a rational design of solid drug nanoparticles with optimised pharmacological properties. Journal of Interdisciplinary Nanomedicine. 2016, 1, 3, 110-123.
  32. R. T. Woodward, D. W. H. Fam, D. B. Anthony, J. Hong, T. O. McDonald, C. Petit, M.S. P. Shaffer, A. Bismarck Hierarchically porous carbon foams from pickering high internal phase emulsions. Carbon. 2016, 101, 253-260.
  33. M. Giardiello, F. L. Hatton, R. A. Slater, P. Chambon, J. North, A. K. Peacock, T. He, T. O. McDonald, A. Owen, S. P. Rannard Stable, polymer-directed and SPION-nucleated magnetic amphiphilic block copolymer nanoprecipitates with readily reversible assembly in magnetic fields. Nanoscale. 2016, 8, (13), 7224-7231.
  34. E. R. Draper, E. G. B. Eden, T. O. McDonald, D. J. Adams Spatially resolved multicomponent gels. Nature chemistry. 2015, 7, 10, 848-852.
  35. S. Awhida, E. R. Draper, T. O. McDonald, D. J. Adams, Probing Gelation Ability for a Library of Dipeptide Gelators. Journal of Colloid and Interface Science. 455, 2015, 24–31.
  36. P. J. Martin, M. Giardiello, T. O. McDonald, D. L. Smith, M. Siccardi, S. P Rannard, A. Owen, Augmented inhibition of CYP3A4 in human primary hepatocytes by ritonavir solid drug nanoparticles. Molecular pharmaceutics. 2015, 12 (10), 3556-3568
  37. A. K. Das, I. Maity, H. S. Parmar, T. O. McDonald, M. Konda, Lipase Catalyzed Dissipative Self-Assembly of a Thixotropic Peptide Bolaamphiphile Hydrogel for Human Umbilical Cord Stem Cells Proliferation. Biomacromolecules. 2015, 16, 4, 1157–1168
  38. E. R. Draper, L. L. E. Mears, A. M. Castilla, S. M. King, T. O. McDonald, R. Akhtar, D. J. Adams Using the hydrolysis of anhydrides to control gel properties and homogeneity in pH-triggered gelation. RSC Advances. 2015, 5, 95369-95378
  39. E. R. Draper, T. O. McDonald, D. J. Adams, Photodimerisation of a coumarin-dipeptide gelator. Chemical Communications. 2015, 51, 12827-12830.
  40. E. R. Draper, K. L. Morris, M. A Little, J. Raeburn, C. Colquhoun, E. R. Cross, T. O. McDonald, L. C. Serpell, D. J. Adams Hydrogels formed from Fmoc amino acids CrystEngComm, 2015, 17 (42), 8047-8057
  41. P. Kubiak, S. Awhida, C. Hotchen, W. Deng, B. M. Alston, T. O. McDonald, D. J. Adams, P. J. Cameron, Polymerization of low molecular weight hydrogelators to form electrochromic polymers Chemical Communications 2015, 51, 10427-10430
  42. E. R. Draper, T. O. McDonald, D. J. Adams, A low molecular weight hydrogel with unusual gel aging. Chemical Communications. 2015, 51, 30, 6595-6597.
  43. T. O. McDonald, R. Akhtar, C. H. Lau, T. Ratvijitvech, G. Cheng, R. Clowes, D. Adams, T. Hasell, A. Cooper, Using Intermolecular Interactions to Crosslink PIM-1 and Modify its Gas Sorption Properties. Journal of Materials Chemistry A, 2015. 3, 9, 4855-4864.
  44. T. O. McDonald; M. Giardiello; P. Martin; M. Siccardi; N. J. Liptrott; D. Smith; P. Roberts; P. Curley; A. Schipani; S. H. Khoo; J. Long; A. J. Foster; S. P. Rannard; A. Owen, Antiretroviral solid drug nanoparticles with enhanced oral bioavailability: production, characterization, and in vitro–in vivo correlation. Advanced Healthcare Materials, 2014, 3, 400-411.
  45. C. Butchosa, T. O. McDonald, A. I. Cooper, D. J. Adams and M. A. Zwijnenburg, Shining a Light on s-Triazine-Based Polymers. The Journal of Physical Chemistry C, 2014, 118, 4314-4324.
  46. J. Raeburn, B. Alston, J. Kroeger, T. O. McDonald, J. R. Howse, P. J. Cameron and D. J. Adams, Electrochemically-triggered spatially and temporally resolved multi-component gels. Mater. Horiz., 2014, 1, 241-246.
  47. C. Colquhoun, E. R. Draper, E. G. B. Eden, B. N. Cattoz, K. L. Morris, L. Chen, T. O. McDonald, A. E. Terry, P. C. Griffiths, L. C. Serpell and D. J. Adams, The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels. Nanoscale, 2014, 6, 13719-13725.
  48. E. R. Draper, J. J. Walsh, T. O. McDonald, M. A. Zwijnenburg, P. J. Cameron, A. J. Cowan and D. J. Adams, Air-stable Photoconductive Films formed from Perylene Bisimide Gelators. Journal of Materials Chemistry C, 2014, 2, 5570-5575.
  49. F. L. Hatton, P. Chambon, T. O. McDonald, A. Owen and S. P. Rannard, Hyperbranched polydendrons: a new controlled macromolecular architecture with self-assembly in water and organic solvents. Chemical Science, 2014, 5, 1844-1853.
  50. F. Blanc, S. Y. Chong, T. O. McDonald, D. J. Adams, S. Pawsey, M. A. Caporini and A. I. Cooper, Dynamic nuclear polarization NMR spectroscopy allows high-throughput characterization of microporous organic polymers. Journal of the American Chemical Society, 2013, 135, 15290-15293.
  51. M. A. Zwijnenburg, G. Cheng, T. O. McDonald, K. E. Jelfs, J.-X. Jiang, S. Ren, T. Hasell, F. Blanc, A. I. Cooper and D. J. Adams, Shedding Light on Structure–Property Relationships for Conjugated Microporous Polymers: The Importance of Rings and Strain. Macromolecules, 2013, 46, 7696-7704.
  52. P. Martin, M. Giardiello, T. O. McDonald, S. P. Rannard and A. Owen, Mediation of in vitro cytochrome P450 activity by common pharmaceutical excipients. Molecular pharmaceutics, 2013, 10, 2739-2748.
  53. M. Siccardi, P. Martin, T. O. McDonald, N. J. Liptrott, M. Giardiello, S. Rannard and A. Owen, Research Spotlight: Nanomedicines for HIV therapy. Therapeutic delivery, 2013, 4, 153-156.
  54. L. Chen, T. O. McDonald and D. J. Adams, Salt-induced hydrogels from functionalised-dipeptides. RSC Adv., 2013, 3, 8714-8720.
  55. M. Giardiello, T. O. McDonald, J.-S. Lee, A. D. Roberts, A. Owen and S. P. Rannard, Reactions of hydrophobic organic nanoparticle mixtures in water: nanoparticle-on-nanoparticle oxidative dye bleaching. Green Chem., 2013, 15, 1590-1599.
  56. T. O. McDonald, L. M. Tatham, F. Y. Southworth, M. Giardiello, P. Martin, N. J. Liptrott, A. Owen and S. P. Rannard, High-throughput nanoprecipitation of the organic antimicrobial triclosan and enhancement of activity against Escherichia coli. Journal of Materials Chemistry B, 2013, 1, 4455-4465.
  57. M. Zelzer, S. J. Todd, A. R. Hirst, T. O. McDonald and R. V. Ulijn, Enzyme responsive materials: design strategies and future developments. Biomaterials Science, 2013, 1, 11-39.
  58. J. Raeburn, T. O. McDonald and D. J. Adams, Dipeptide hydrogelation triggered via ultraviolet light. Chem. Commun., 2012, 48, 9355-9357.
  59. T. O. McDonald, P. Martin, J. P. Patterson, D. Smith, M. Giardiello, M. Marcello, V. See, R. K. O’Reilly, A. Owen and S. Rannard, Multicomponent organic nanoparticles for fluorescence studies in biological systems. Advanced Functional Materials, 2012, 22, 2469-2478.
  60. M. Giardiello, T. O. McDonald, P. Martin, A. Owen and S. P. Rannard, Facile synthesis of complex multi-component organic and organic–magnetic inorganic nanocomposite particles. Journal of Materials Chemistry, 2012, 22, 24744-24752.
  61. R. A. Slater, T. O. McDonald, D. J. Adams, E. R. Draper, J. V. M. Weaver and S. P. Rannard, Architecture-driven aqueous stability of hydrophobic, branched polymer nanoparticles prepared by rapid nanoprecipitation. Soft Matter, 2012, 8, 9816-9827.
  62. R. L. Harbron, T. O. McDonald, S. P. Rannard, P. H. Findlay and J. V. M. Weaver, One-pot, single-component synthesis of functional emulsion-templated hybrid inorganic–organic polymer capsules. Chemical Communications, 2012, 48, 1592-1594.
  63. T. O. McDonald, H. L. Qu, B. R. Saunders and R. V. Ulijn, Branched peptide actuators for enzyme responsive hydrogel particles. Soft Matter, 2009, 5, 1728-1734.

Book Chapters

  1. T. O. McDonald, M. Siccardi, D. Moss, N. Liptrott, M. Giardiello, S. Rannard, A. Owen, The Application of Nanotechnology to Drug Delivery in Medicine, Nanoengineering: Global Approaches to Health and Safety Issues, 2015, Elsevier.
  2. T. McDonald, A. Patrick, R. Williams, B. G. Cousins, R. V. Ulijn, Bio-responsive hydrogels for biomedical applications. Biomedical Applications of Electroactive Polymer Actuators. 2009, John Wiley & Sons, Ltd.